Ingrediants: Cascara Sagrada, Pau D'Arco, Epazote, Chanca Piedra, Sarsaparilla.
Cascara Sagrada - used by Native Americans for digestive issues. This bark strengthens and tightens the intestines, replenishes healthy bacteria and cleans waste from the digestive system.
Pau D'arco - in the 1960s, extracts demonstrated marked antitumorous effects in animals, which drewthe interest of the National CancerInstitute(NCI). Researchers decided thatthe most potent singlechemical for this activity was a naphthoquinone chemical named lapachol and they concentrated solely on this single chemical in theirsubsequentcancer research. In a 1968 study, lapachol demonstrated highly significant activity against cancerous tumors in rats. By 1970, NCI-backed research already was testing lapachol in human cancer patients. The institute reported, however, that their first Phase I study failed to produce a therapeutic effect without side effects—and they discontinued further cancer research shortly thereafter. These side effects were nausea and vomiting and anti-vitamin K activity. Interestingly, other chemicals in the whole plant extract (which,initially, showed positive antitumor effects at very low toxicity) demonstrated positive effects on vitamin K and, conceivably, compensated for lapachol's negative effect. Once again, instead of pursuing research on a complex combination of at least 20 active chemicals in a whole plant extract (several of which had anti-tumor effects and otherpositive biological activities), research focused on a single, patentable chemical—and it didn't work as well. Despite NCI's abandonment of the research, another group developed a lapachol analog (which was patentable) in 1975. One study reported that this lapachol analog increasedthe life span of miceinoculated with leukemic cells by over 80%. In a small, uncontrolled,1980 study of nine human patients with various cancers (liver, kidney, breast,prostate,and cervix), pure lapachol was reported to shrink tumors and reduce pain caused by them—and three of the patients realized complete remissions. Another chemical in pau d'arco, beta-lapachone,has been studied closely oflate and a number ofrecent patents have been filed on it. It has demonstrated in laboratory studies to have activities similar tolapachol (antimicrobial, antifungal, antiviral, antitumorous, antileukemic, and anti-inflammatory), with fewside effects. Research published from2003 to 2005 provides important new insights into the possible molecular mechanisms of the anti-cancer activity ofbeta-lapachone specificallyagainst prostate,colon,pancreatic,and lungcancers.In a 2002 U.S.patent,beta-lapachone was cited to have significant anti-cancerous activity against human cancer cell lines including: promyelocytic leukemia, prostate, malignant glioma,colon,hepatoma, breast, ovarian, pancreatic,multiple myelomacell lines and drug-resistant cell lines. In yet another U.S. patent,beta-lapachone was cited with the in vivo-ability to inhibit the growth of prostate tumors.
Epazote - Epazote leaf extract was given to 72 children and adults with intestinal parasitic infections in a clinical study. On average, an antiparasitic efficacy was seen in 56% of cases. With respect to the tested parasites, epazote leaf extract was reported to be 100% effective against the common intestina lparasites, Ancilostoma and Trichuris, and, 50% effective against Ascaris. In 2001,thirty children with intestinal roundworms were treated with epazote. Disappearance ofthe Ascaris eggs occurred in 86.7%, while the parasitic burden decreased in 59.5%. In addition, this study also reported that epazote was 100% effective in eliminating Hymenolepsis nana (common human tapeworm).
Contraindications: This plant has been documented with uterine stimulant and uterine antispasmodic actions in animal studies and is contraindicated in pregnancy. Drug Interactions: May potentiate diuretic drugs. Other Practitioner Observations and Possible Precautions: Chanca piedra has been documented to reduce blood pressure in animal studies. Individuals with low blood pressure should be monitored for this effect. Chanca piedra has been documented with female antifertility effects in one mouse study (the effect was reversed 45 days after cessation of dosing). While this effect has not been documented in humans, the use of the plant is probably contraindicated in women seeking pregnancy or taking fertility drugs.
This plant has demonstrated hypoglycemic activity in animalIn over 20 laboratory tests in animals and in humans, chanca piedra has shown significant antiviral effects against Hepatitis B (HBV). Not only has it been reported to provide a direct antiviral effect, it has also been reported to clear the surface antigen from chronic carriers. A Chinese research group published a study in 2001 which compared 30 chronic HBV patients taking a chanca piedra extract to 25 patients taking interferon for three months. Both treatments showed an equal effectiveness of 83%, but the chanca piedra group rated significantly higher in the normalization of liver enzymes and recovery of liver function than the interferon-treated group. They published yet another study in 2003 which attributed the anti-HVB effects mainly to four chemicals in chanca piedra: niranthin, nirtetralin, hinokinin, and geraniin. The Cochrane Hepato-Biliary Research Group in Copenhagen reviewed all the HBV published research (22 randomized trials) and published an independent review of the results. It stated that chanca piedra had "a positive effect on clearance of serum HBsAg (HBV surface antigen) comparable to interferon and was better than nonspecific treatment or other herbal medicines for HBV and liver enzyme normalization.” A Japanese research group reported that a simple water extract of chanca piedra inhibited HIV-1 reverse transcriptase in 1992. They attributed this effect to a plant chemical in chanca piedra called repandusinic acid A. When they tested this chemical individually it demonstrated significant toxicity to HIV-1 at very small dosages (a 90% in vitro inhibition using only 2.5 mcg). Bristol-Myers Squibb Pharmaceutical Research Institute isolated yet another chemical in chanca piedra with anti-HIV actions—a novel compound that they named niruriside and described in a 1996 study. A German research organization published their first study on chanca piedra and its application with HIV therapy (reporting a 70-75% inhibition of viral replication) in 2003. In addition to these antiviral properties, the plant has also been documented other antimicrobial effects. In several laboratory studies chanca piedra demonstrated antibacterial actions against Staphylococcus, Micrococcus, and Pasteurella bacteria as well as in vivo and in vitro anti-malarial properties. Research published in 2006 by researchers in India reported chanca piedra showed significant concentration dependent antibacterial activity particularly against Gram-negative bacteria.
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DECOLONISE Herbal Capsules